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Elsevier, Bioorganic and Medicinal Chemistry Letters, 3(20), p. 1202-1204

DOI: 10.1016/j.bmcl.2009.11.135

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Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting

Journal article published in 2010 by Sara N. Richter ORCID, Richter Sn, Ilaria Frasson, Manlio Palumbo, Claudia Sissi, Palu' G., Giorgio Palù
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Simocyclinone D8 (SD8) is known to affect Gram-positive bacteria only. By testing SD8 against several clinical isolates, we showed that SD8 resulted very active against Gram-negative bacteria from clinical specimens, while it was shown inactive against laboratory strains. The activity against the former was in part due to enhanced drug entry. In addition, SD8 appears to share chromosome- and plasmid-mediated resistance mechanisms with fluoroquinolones.