Dissemin is shutting down on January 1st, 2025

Published in

Springer Nature [academic journals on nature.com], British Journal of Cancer, 7(108), p. 1552-1552, 2013

DOI: 10.1038/bjc.2013.111

Springer Nature [academic journals on nature.com], British Journal of Cancer, 9(107), p. 1618-1623, 2012

DOI: 10.1038/bjc.2012.449

Links

Tools

Export citation

Search in Google Scholar

Hookah smoking, nass chewing, and oesophageal squamous cell carcinoma in Kashmir, India

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Orange circle
Postprint: archiving restricted
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO

Abstract

Dar, N A Bhat, G A Shah, I A Iqbal, B Makhdoomi, M A Nisar, I Rafiq, R Iqbal, S T Bhat, A B Nabi, S Shah, S A Shafi, R Masood, A Lone, M M Zargar, S A Najar, M S Islami, F Boffetta, P eng Research Support, Non-U.S. Gov't England 2012/10/04 06:00 Br J Cancer. 2012 Oct 23;107(9):1618-23. doi: 10.1038/bjc.2012.449. Epub 2012 Oct 2. ; International audience ; BACKGROUND: Although cigarette smoking is an established risk factor for oesophageal squamous cell carcinoma (ESCC), there is little information about the association between other smoking and smokeless tobacco products, including hookah and nass, and ESCC risk. We conducted a case-control study in Kashmir Valley, India, where hookah smoking, nass chewing, and ESCC are common, to investigate the association of hookah smoking, nass use, and several other habits with ESCC. METHODS: We recruited 702 histologically confirmed ESCC cases and 1663 hospital-based controls, individually matched to the cases for age, sex, and district of residence from September 2008 to January 2012. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: Ever-hookah smoking (OR=1.85; 95% CI, 1.41-2.44) and nass chewing (OR=2.88; 95% CI, 2.06-4.04) were associated with ESCC risk. These associations were consistent across different measures of use, including intensity, duration, and cumulative amount of use, and after excluding ever users of the other product and cigarette smokers. Our results also suggest an increased risk of ESCC associated with ever-gutka chewing and -bidi smoking. However, the latter associations were based on small number of participants. CONCLUSION: This study shows that hookah and nass use are associated with ESCC risk. As prevalence of hookah use seems to be increasing among young people worldwide, these results may have relevance not only for the regions in which hookah use has been a traditional habit, but also for other regions, including western countries.