Published in
Bohn Stafleu van Loghum, Critical Care, 1(18), p. R18
DOI: 10.1186/cc13699
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- Bohn Stafleu van Loghum | PDF
- [discovery.ucl.ac.uk]
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study.
Journal article published in 2014 by
Luuk Wieske,
Esther Witteveen,
Axel Petzold 
,
Camiel Verhamme,
Mj Schultz,
In van Schaik,
Janneke Horn
,
Camiel Verhamme,
Mj Schultz,
In van Schaik,
Janneke Horn
This paper is made freely available by the publisher.
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Abstract
Early diagnosis of intensive care unit - acquired weakness (ICU-AW) using the current reference standard, that is, assessment of muscle strength, is often hampered due to impaired consciousness. Biological markers could solve this problem but have been scarcely investigated. We hypothesized that plasma levels of neurofilaments are elevated in ICU-AW and can diagnose ICU-AW before muscle strength assessment is possible.