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Taylor and Francis Group, Epigenetics, 1(9), p. 27-36, 2013

DOI: 10.4161/epi.26942

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RNA-mediated gene activation

Journal article published in 2013 by Alan L. Jiao, Frank J. Slack ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The regulation of gene expression by non-coding RNAs (ncRNAs) has become a new paradigm in biology. RNA-mediated gene silencing pathways have been studied extensively, revealing diverse epigenetic and posttranscriptional mechanisms. In contrast, the roles of ncRNAs in activating gene expression remains poorly understood. In this review, we summarize the current knowledge of gene activation by small RNAs, long non-coding RNAs, and enhancer-derived RNAs, with an emphasis on epigenetic mechanisms.