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Oxford University Press, The Journal of Clinical Endocrinology & Metabolism, 5(95), p. 2433-2442, 2010

DOI: 10.1210/jc.2010-0023

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Differential Expression Profile ofGrowth Hormone/Chorionic SomatomammotropinGenes in Placenta of Small- and Large-for-Gestational-Age Newborns

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Context: The human growth hormone/chorionic somatomammotropin (hGH/CSH) locus at 17q22-24, consisting of one pituitary-expressed postnatal (GH1) and four placenta-expressed genes (GH2, CSH1, CSH2, and CSHL1), is implicated in regulation of postnatal and intrauterine growth. A positive correlation has been reported between the offspring’s birth weight and serum placental GH (coded by GH2) and placental lactogen (coded by CSH1, CSH2) levels in pregnant women.