Wiley, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 7S_Part_15(12), 2016
DOI: 10.1016/j.jalz.2016.06.1542
Wiley, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 7S_Part_1(12), 2016
DOI: 10.1016/j.jalz.2016.06.075
Elsevier, Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2016.02.017
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Directed information flow between brain regions might be disrupted in dementia with Lewy bodies (DLB) and relate to the clinical syndrome of DLB. To investigate this hypothesis, resting-state electroencephalography recordings were obtained in patients with probable DLB and Alzheimer's disease (AD), and controls (N = 66 per group, matched for age and gender). Phase transfer entropy was used to measure directed connectivity in the groups for the theta, alpha, and beta frequency band. A posterior-to-anterior phase transfer entropy gradient, with occipital channels driving the frontal channels, was found in controls in all frequency bands. This posterior-to-anterior gradient was largely lost in DLB in the alpha band (p