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BioMed Central, Diagnostic Pathology, 1(10), 2015

DOI: 10.1186/s13000-015-0290-4

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Assessment of a panel of tumor markers for the differential diagnosis of benign and malignant effusions by well-based reverse phase protein array

Journal article published in 2015 by Till Braunschweig ORCID, Joon-Yong Chung ORCID, Chel Hun Choi, Hanbyoul Cho, Qing-Rong Chen, Ran Xie, Candice Perry, Javed Khan, Stephen M. Hewitt ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background The differential diagnosis of benign and malignant effusion is often hampered by low cell content or insufficiently preserved tumor cells. In this study, we evaluated the combined diagnostic value of six tumor markers measured by well-based reverse-phase protein array (RPPA) for diagnosis of malignant effusion. Methods A total of 114 patients (46 with malignant effusions, 32 with probable malignant effusions, and 36 with benign effusions) were enrolled. Expressional levels of MUC1, EMA, Pan-CK, HSP90, TGF-β and CA125 were determined by well-based RPPA. Results Median relative expression of MUC1, Pan-CK and EMA were significantly higher in malignant effusion than those in probable malignant or benign ( p