Published in
Oxford University Press, Nephrology Dialysis Transplantation, 8(24), p. 2428-2433, 2009
DOI: 10.1093/ndt/gfp116
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Nephron number and individual glomerular volumes in male Caucasian and African American subjects
,
Rebecca N. Douglas-Denton,
Michael D. Hughson,
Libby M. Holden,
John F. Bertram
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Abstract
Background. Glomerular hypertrophy has been described in several populations at high risk of chronic kidney disease. Total nephron (and thereby glomerular) number (Nglom) varies widely in normal adult human kidneys and is generally inversely correlated with mean glomerular volume (Vglom). However, little is known about the range of individual glomerular volumes (IVglom) within single human kidneys and the association with Nglom. The aim of the present study was to estimate IVglom in Caucasian and African Americans and identify any associations between heterogeneity in IVglom and nephron number. Methods. Using unbiased stereological techniques, IVglom was determined for 30 glomeruli in each of 24 adult male kidneys from Jackson, MS, USA (12 Caucasian and 12 African American). Half of each group had ‘high’ Nglom (>1.2 million nephrons per kidney) and the other half had ‘low’ Nglom (