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BioMed Central, Journal of Hematology and Oncology, 1(7), 2014

DOI: 10.1186/s13045-014-0084-2

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MicroRNA-mediated regulation of KRAS in cancer

Journal article published in 2014 by Minlee Kim, Frank J. Slack ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.