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Mary Ann Liebert, Antioxidants and Redox Signaling, 4(14), p. 623-634, 2011

DOI: 10.1089/ars.2010.3490

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DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

Journal article published in 2011 by Kelvin Yen ORCID, Sri Devi Narasimhan, Heidi A. Tissenbaum
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The Caenorhabditis elegans Forkhead box O transcription factor (FOXO) homolog DAF-16 functions as a central mediator of multiple biological processes such as longevity, development, fat storage, stress resistance, and reproduction. In C. elegans, similar to other systems, DAF-16 functions as the downstream target of a conserved, well-characterized insulin/insulin-like growth factor (IGF)-1 signaling pathway. This cascade is comprised of an insulin/IGF-1 receptor, which signals through a conserved PI 3-kinase/AKT pathway that ultimately downregulates DAF-16/FOXO activity. Importantly, studies have shown that multiple pathways intersect with the insulin/IGF-1 signaling pathway and impinge on DAF-16 for their regulation. Therefore, in C. elegans, the single FOXO family member, DAF-16, integrates signals from several pathways and then regulates its many downstream target genes. Antioxid. Redox Signal. 14, 623–634.