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BioMed Central, Journal of Hematology and Oncology, 1(7), 2014

DOI: 10.1186/s13045-014-0083-3

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MicroRNA-binding site polymorphisms in hematological malignancies

Journal article published in 2014 by Agnieszka Dzikiewicz-Krawczyk ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dysregulation of microRNA networks has been implicated in hematological malignancies. One of the reasons for disturbed miRNA-mediated regulation are polymorphisms in miRNA-binding sites (miRSNPs), which alter the strength of miRNA interaction with target transcripts. In the recent years the first findings of miRSNPs associated with risk and prognosis in hematological malignancies have been reported. From the studies described in this review miRSNPs not only emerge as novel markers of risk and prognosis but can also lead to better understanding of the role of miRNAs in regulating gene expression in health and disease.