Genome sequence and analysis of the tuber crop potato

All 120 authors (show less):
Xun Xu, Roeland C. H. J. van Ham, Shengkai Pan, Shifeng Cheng, Bo Zhang, Desheng Mu, Peixiang Ni, Gengyun Zhang, S. Yang (Principal, Shuang Yang, Ruiqiang Li, R. Li (Principal, Jun Wang, J. Wang (Principal, G. Orjeda (Principal, Gisella Orjeda, Frank Guzman, Michael Torres, Roberto Lozano, Olga Ponce, Diana Martinez, Germán De la Cruz, S. K. Chakrabarti (Principal, S. K. Chakrabarti, Virupaksh U. Patil, K. G. Skryabin (Principal, Konstantin G. Skryabin, Boris B. Kuznetsov, Nikolai V. Ravin, Tatjana V. Kolganova, Alexey V. Beletsky, Andrei V. Mardanov, Alex Di Genova, D. Martin (Principal, Daniel M. BolserORCID, David M. A. Martin, Guangcun Li, Yu Yang, Hanhui Kuang, Qun Hu, Xingyao Xiong, B. Sagredo (Principal, Gerard J. Bishop, Boris Sagredo, W. Zagorski (Principal, Nilo Mejía, Wlodzimierz Zagorski, Robert Gromadka, Jan Gawor, S. Huang (Principal, Pawel Szczesny, Sanwen Huang, Zhonghua Zhang, Chunbo Liang, Jun He, Ying Li, Ying He, Jianfei Xu, Youjun Zhang, Binyan Xie, D. Qu (Principal, Yongchen Du, Dongyu Qu, Merideth Bonierbale, Marc Ghislain, G. Giuliano (Principal, Maria del Rosario Herrera, Maria del Rosario Herrera, Marco Pietrella, Giovanni Giuliano, Gaetano Perrotta, Kimberly O'Brien, Paolo Facella, S. E. Feingold (Principal, Kimberly O’Brien, Leandro E. Barreiro, Sergio E. Feingold, Gabriela A. Massa, Luis Diambra, Brett R. Whitty, Brieanne Vaillancourt, Haining Lin, Alicia N. Massa, Michael Geoffroy, C. Robin Buell (Principal, Steven Lundback, Dean DellaPenna, Sanjeev Kumar Sharma, C. Robin Buell, David F. Marshall, G. J. Bryan (Principal, Robbie Waugh, Glenn J. Bryan, Marialaura Destefanis, Istvan Nagy, Dan Milbourne, D. Milbourne (Principal, Susan J. Thomson, Mark Fiers, Jeanne M. E. Jacobs, J. M. E. Jacobs (Principal, K. L. Nielsen (Principal, Kåre L. Nielsen, Mads Sønderkær, Marina Iovene, Giovana A. Torres, J. Jiang (Principal, Jiming Jiang, Richard E. Veilleux, C. W. B. Bachem (Principal, Christian W. B. Bachem, Jan de Boer, Theo Borm, Bjorn Kloosterman, Herman van Eck, Erwin Datema, Bas te Lintel Hekkert, Bas te Lintel Hekkert, Aska Goverse, Richard G. F. Visser

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Abstract
Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop.