Dissemin is shutting down on January 1st, 2025

Published in

Springer Nature [academic journals on nature.com], British Journal of Cancer, 8(84), p. 1122-1125

DOI: 10.1054/bjoc.2000.1719

Links

Tools

Export citation

Search in Google Scholar

Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase

Journal article published in 2001 by D. L. Van den Berge, Dirk L. Van Den Berge, Mark M. De Ridder ORCID, M. De Ridder, Valeri N. Verovski, Marleen M. Y. Janssens, Christinne Monsaert, Guy A. Storme
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta, Low concentrations of cytokines (1 unit ml-1) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign. ; SCOPUS: ar.j ; info:eu-repo/semantics/published