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Oxford University Press (OUP), Journal of Clinical Endocrinology and Metabolism, 8(94), p. 2792-2798

DOI: 10.1210/jc.2008-2157

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A Cohort Study of Thiazolidinediones and Fractures in Older Adults with Diabetes

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Context: Thiazolidenediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor-γ and have been shown to reduce bone mineral density. Recent results from several randomized controlled trials find an increased risk of fracture with TZDs compared with other oral antidiabetic agents.