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American Chemical Society, Nano Letters, 1(8), p. 56-63, 2007

DOI: 10.1021/nl071890k

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Detection of DNA sequences using an alternating electric field in a nanopore capacitor

Journal article published in 2007 by Grigori Sigalov, Jeffrey Comer, Gregory Timp, Aleksei Aksimentiev ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Molecular dynamics simulations revealed that back-and-forth motion of DNA strands through a 1 nm diameter pore exhibits sequence-specific hysteresis that arises from the reorientation of the DNA bases in the nanopore constriction. Such hysteresis of the DNA motion results in detectable changes of the electrostatic potential at the electrodes of the nanopore capacitor and in a sequence-specific drift of the DNA strand under an oscillating transmembrane bias. A strategy is suggested for sequencing DNA in a nanopore using the electric field that alternates periodically in time.