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Elsevier, Journal of Affective Disorders, (190), p. 640-648, 2016

DOI: 10.1016/j.jad.2015.10.050

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Anhedonia is associated with blunted reward sensitivity in first-degree relatives of patients with major depression

Journal article published in 2016 by Wen-Hua Liu, Jonathan P. Roiser, Ling-Zhi Wang, Yu-Hua Zhu, Jia Huang, David L. Neumann, David H. K. Shum, Eric F. C. Cheung, Raymond C. K. Chan
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This paper is available in a repository.

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Abstract

Background: Anhedonia is a cardinal feature of major depression and is hypothesized to be driven by low motivation, in particular blunted reward sensitivity. It has been suggested to be a marker that represents a genetic predisposition to this disorder. However, little is known about the mechanisms underlying this heightened risk in unaffected first-degree relatives of patients with major depression. We previously demonstrated abnormal reward biases in acutely depressed patients. The present study aimed to examine the development of reward bias in first-degree relatives of patients with major depression.