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Rockefeller University Press, Journal of Cell Biology, 6(202), p. 837-848, 2013

DOI: 10.1083/jcb.201305098

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Cellular and molecular mechanisms underlying axon formation, growth, and branching

Journal article published in 2013 by Tommy L. Lewis, Julien Courchet, Franck Polleux ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries have provided insight into many aspects of the cell biology of axonal development including axon specification during neuronal polarization, axon growth, and terminal axon branching during synaptogenesis.