Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 39(112), p. 12005-12010, 2015
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Creation of a histone deacetylase 6 inhibitor and its biological effects
Journal article published in 2015 by
Ju-Hee Lee,
Yuanshan Yao,
Adaickapillai Mahendran,
Lang Ngo,
Gisela Venta-Perez,
Megan L. Choy,
Ronald Breslow,
Paul A. Marks
This paper is made freely available by the publisher.
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Abstract
Significance We discovered an improved hydroxamic acid-based small-molecule N-hydroxy-4-[(N(2-hydroxyethyl)-2-phenylacetamido)methyl)benzamide)] that selectively inhibits histone deacetylase 6 catalytic activity in vivo and in vitro. This can have important anticancer activity.