Published in

MDPI, Sensors, 2(15), p. 4229-4241, 2015

DOI: 10.3390/s150204229

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Microbial Biofilm as a Smart Material

Journal article published in 2015 by Christian Garde, Martin Welch, Jesper Ferkinghoff-Borg, Thomas Sams
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Microbial biofilm colonies will in many cases form a smart material capable of responding to external threats dependent on their size and internal state. The microbial community accordingly switches between passive, protective, or attack modes of action. In order to decide which strategy to employ, it is essential for the biofilm community to be able to sense its own size. The sensor designed to perform this task is termed a quorum sensor, since it only permits collective behaviour once a sufficiently large assembly of microbes have been established. The generic quorum sensor construct involves two genes, one coding for the production of a diffusible signal molecule and one coding for a regulator protein dedicated to sensing the signal molecules. A positive feedback in the signal molecule production sets a well-defined condition for switching into the collective mode. The activation of the regulator involves a slow dimerization, which allows low-pass filtering of the activation of the collective mode. Here, we review and combine the model components that form the basic quorum sensor in a number of Gram-negative bacteria, e.g., Pseudomonas aeruginosa.