Published in
MDPI, Marine Drugs, 6(9), p. 1133-1141, 2011
DOI: 10.3390/md9061133
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
,
Simona De Marino,
Carmen Festa ,
Maria Valeria D'Auria,
Maria Valeria D’Auria,
Thierry Cresteil,
Cecile Debitus,
Angela Zampella
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Abstract
In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.