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Wiley, Chemistry - A European Journal, 1(19), p. 78-81, 2012
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Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane
Journal article published in 2012 by
Filippo Doria,
Matteo Nadai,
Marco Folini 
,
Matteo Scalabrin,
Luca Germani,
Giovanna Sattin,
Mariella Mella,
Manlio Palumbo,
Nadia Zaffaroni,
Daniele Fabris,
Mauro Freccero ,
Sara N. Richter
,
Matteo Scalabrin,
Luca Germani,
Giovanna Sattin,
Mariella Mella,
Manlio Palumbo,
Nadia Zaffaroni,
Daniele Fabris,
Mauro Freccero ,
Sara N. Richter
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Abstract
Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.