Links

Tools

Export citation

Search in Google Scholar

Xuan Xue. Transition Met. Chem. 2016, 41(3), 331–337-SI

Journal article published in 2016 by Xuan Xue, Jiafeng Wang, Guifu Si, Chengming Wang, Shuangsheng Zhou
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Question mark in circle
Preprint: policy unknown
Question mark in circle
Postprint: policy unknown
Question mark in circle
Published version: policy unknown

Abstract

Two Cu(II) complexes based on curcumin, namely CuL2 1 [HL1 = 1,7-bis[4-(2-oxymethylenepyridine)-3-methoxyl]phenyl-1,6-heptadiene-3,5-diketone] and CuL2 2 [HL2 = 1,7-bis[4-(3-oxymethylene-2-chlorothiophene)-3-methoxyl] phenyl-1,6-heptadiene-3,5-diketone], have been synthesized and characterized by physico-chemical and spectroscopic methods. The interactions of calf thymus DNA (CT-DNA) with both complexes have been investigated by UV–Vis absorption, fluorescence and viscosity titration methods. Both complexes are found to interactwith CT-DNA by intercalative binding modes. Evaluation of the cytotoxicities of the complexes against three human tumor cells showed that they have potent cytotoxicities against all three cell lines.