American Chemical Society, Biomacromolecules, 4(17), p. 1261-1271, 2016
DOI: 10.1021/acs.biomac.5b01037
Full text: Unavailable
There is considerable interest in combining bioactive polymers such as chitosan with titanium bone implants to promote bone healing and provide therapeutic needs. However, the fate of these biodegradable polymers especially on titanium implant is not fully explored. Here we report in-situ formation of chitosan microtube (CMTs) structures from chitosan films on the implant surface with titania nanotubes (TNTs) layer based on phosphate buffer-induced transformation and precipitation process. We have comprehensively analyzed this phenomenon and the factors that influence CMT formation, including substrate topography, the immersion solution and its pH, the effect of coating thickness and the time of immersion. Significance of reported in-situ formation of chitosan microtubes on the TNTs surface is possibility to tailor properties of implants with favorable micro and nano morphology using self-ordering process after implant's insertion.