WELCOME project aims at the development of a technical solution that will leverage integrated care of COPD and comorbidities via wearable technologies, user applications and cloud computing. This work focuses on the latter part and proposes technological approaches that will enable standardized cloud based data management and analytics in a challenging multimorbid health scenario. WELCOME cloud approach encompasses the data model and semantics binding to HL7FHIR, the persistent data storage for performance and scalability, and the orchestration in a loose coupling with the feature extraction services. While DSS is currently being built on existing clinical knowledge combining the calculated features, the richness of new features and their solid semantics will enable the generation of new knowledge towards a learning health system. This can leverage coordinated care for the management of COPD and comorbidities.