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Public Library of Science, PLoS ONE, 3(11), p. e0151335, 2016

DOI: 10.1371/journal.pone.0151335

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Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo

Journal article published in 2016 by Corinna Rosenbaum, Martin Alexander Schick, Jakob Wollborn, Andreas Heider, Claus-Jürgen Scholz ORCID, Alexander Cecil, Beate Niesler, Johannes Hirrlinger, Heike Walles, Marco Metzger
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Enteric glial cells (EGCs) are the main constituent of the enteric nervous system and share similarities with astrocytes from the central nervous system including their reactivity to an inflammatory microenvironment. Previous studies on EGC pathophysiology have specifically focused on mucosal glia activation and its contribution to mucosal inflammatory processes observed in the gut of inflammatory bowel disease (IBD) patients. In contrast knowledge is scarce on intestinal inflammation not locally restricted to the mucosa but systemically affecting the intestine and its effect on the overall EGC network.