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American Society of Hematology, Blood, 11(126), p. 1324-1335, 2015

DOI: 10.1182/blood-2015-01-621623

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NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

Journal article published in 2015 by Katarina Ochodnicka-Mackovicova, Mahnoush Bahjat, Timon A. Bloedjes, Chiel Maas, Alexander M. de Bruin, Richard J. Bende ORCID, Carel J. M. van Noesel, Jeroen E. J. Guikema ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Key Points NF-κB and AKT signaling prevent RAG-dependent DNA damage in cycling-transformed pre-B cells. NF-κB activity negatively correlates with RAG expression in B-ALL patients.