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Nature Research, Nature Communications, (7), p. 10495

DOI: 10.1038/ncomms10495

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Journal article published in 2016 by Yingchang Lu, Felix R. (Felix) Day ORCID, Stefan Gustafsson ORCID, Martin L. (Martin) Buchkovich, Jianbo Na, Veronique Bataille, Diana L. (Diana) Cousminer, Zari Dastani, David M. Evans, Alexander W. Drong, Tõnu Esko, D. M. (David) Evans, Åsa K. Hedman, Mario Falchi, Mary F. (Mary Furlan) Feitosa and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometa- bolic disease risk, we conducted a genome-wide association meta-analysis of body fat per- centage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5􏰀10􏰁8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel asso- ciations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.