Nature Research, Nature Communications, (7), p. 10495
To increase our understanding of the genetic basis of adiposity and its links to cardiometa- bolic disease risk, we conducted a genome-wide association meta-analysis of body fat per- centage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel asso- ciations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.