Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

van der Klauw, M. M.; van Vliet-Ostaptchouk, J.; da Morris, A.; Zhao, Jing Hua; Zillikens, Mc Carola; den Heijer, Martin; van der Harst, Pim; Yang, Jian; Yarnell, John W. G.; de Faire, Ulf; van Duijn, Cornelia M.; Randall, Joshua C.; Winkler, Thomas W.; Vedantam, Sailaja; Wood, Andrew R.; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Prokopenko, Inga; Waite, Lindsay Ll; Smith, Albert Vernon; Shuldiner, Alan R.; Thorsteinsdottir, Unnur; Teder-Laving, Maris; Tw, Winkler; Wareham, Nicholas J.; Province, Michael A.; Ripatti, Samuli; Surakka, Ida; Saramies, Jouko; Tuomilehto, Jaakko; Salomaa, Veikko; Schunkert, Heribert; Wichmann, He Erich; Voelzke, Henry; Speliotes, Elizabeth K.; Toenjes, Anke; Wilson, James F.; Uitterlinden, André G G.; Rivadeneira, Fernando; Tyrer, Jonathan; Si, Berndt; Teumer, Alexander; Völzke, Henry; Tönjes, Anke; Tonu, Esko; Spector, Tim D.; Rudan, Igor; Samani, Nilesh J.; Sambrook, Jennifer G.; Vliet-Ostaptchouk, Jana; Sinisalo, Juha; Rivolta, Carlo; Jc, Randall; Tönjes, Anke; Snieder, Harold; Van der Klauw, Melanie Mm; Van Vliet-Ostaptchouk, Jana V.; Shi, Jianxin; Wang, Zhaoming; Ridker, Paul M.; Rose, Lynda M.; Raitakari, Olli; Sager, Hendrik; Schwarz, Peter E. H.; Swift, Amy J.; Kutalik, Zoltán; Uusitupa, Matti; Rauramaa, Rainer; Saaristo, Timo E.; Shungin, Dmitry; Strawbridge, Rona J.; Tremoli, Elena; Thorand, Barbara; To, Kilpeläinen; Winkelmann, Bernhard R.; Virtamo, Jarmo; Wong, Andrew; Stirrups, Kathleen; Wilsgaard, Tom; Rehnberg, Emil; Schlessinger, David; Strachan, David P.; Stefansson, Kari; Qi, Lu; Berndt, Sonja I.; Jackson, Anne U.; Monda, Keri L.; Kilpeläinen, Tuomas O.; Maegi, Reedik; Feitosa, Mary F.; Harst, Pim; Croteau-Chonka, Damien C.; Workalemahu, Tsegaselassie; Li, Shengxu; Day, Felix R.; Mägi, Reedik; Locke, Adam E.; Liang, Liming; Dermitzakis, Emmanouil T.; Dimas, Antigone S.; Karpe, Fredrik; Min, Josine L.; Nicholson, George; Clegg, Deborah J.; Person, Thomas; Au, Jackson; Krohn, Jon P.; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amélie; Froguel, Philippe; Hottenga, Jouke-Jan; Esko, Tõnu; Gronberg, Henrik; Harris, Tamara B.; McArdle, Wendy L.; Caulfield, Mark J.; Munroe, Patricia B.; Grönberg, Henrik; Chen, Yii-Der Ida; Li, Guo; Kl, Monda; Beckmann, Jacques S.; Johnson, Toby; Khaw, Kay-Tee; Mägi, Reedik; Amin, Najaf; Adrienne Cupples, L.; Oostra, Ben A.; Kraja, Aldi T.; Cupples, La Adrienne; Heard-Costa, Nancy L.; Kaprio, Jaakko; Collins, Francis S.; O. Connell, Jeffrey R.; Jula, Antti; Kilpelaeinen, Tuomas O.; Erdmann, Jeanette; Hengstenberg, Christian; Loley, Christina; Lamina, Claudia; Albrecht, Eva; Johansson, Å.; Gieger, Christian; Johansson, Åsa; Erich Wichmann, H.; Hicks, Andrew Aa; Pramstaller, Peter Pp; Kathiresan, Sekar; Li, S.; Penninx, Brenda; Hartikainen, Anna-Liisa; Jarvelin, Marjo-Riitta; Gyllensten, Ulf; Boomsma, Dorret I.; Campbell, Harry; Chanock, Stephen J.; Farrall, Martin; Goel, Anuj; Medina-Gomez, Carolina; Johansson, Åsa; Estrada, Karol; Hofman, Albert; Kiemeney, Lambertus A.; Duijn, Cornelia M.; Maschio, Andrea; Hall, Per; Scherag, Andre; Carola Zillikens, M.; Heijer, Martin den; Kovacs, Peter; Mangino, Massimo; Hayward, Caroline; Hall, Alistair S.; Attwood, Antony Paul; Hung, Joseph; Palmer, Lyle J.; Lokki, Marja-Liisa; Boucher, Gabrielle; Fall, Tove; Huikuri, Heikki; Lorentzon, Mattias; Ohlsson, Claes; Hyppoenen, Elina; Eklund, Niina; Eriksson, Johan G.; Barlassina, Cristina; Nolte, Ilja M.; Gejman, Pablo V.; Ferreira, Teresa; Jacobs, Kevin B.; Bakker, Stephan J. L.; Mateo Leach, Irene; Navis, Gerjan; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Chasman, Daniel I.; Mf, Feitosa; Leach, Irene Mateo; Lehtimäki, Terho; Gustafsson, Stefan; Absher, Devin; Iribarren, Carlos; Basart, Hanneke; Hovingh, Kees G.; Hyppönen, Elina; Power, Chris; Anderson, Denise; Beilby, John P.; Hui, Jennie; Jolley, Jennifer; Dc, Croteau Chonka; Noethen, Markus M.; Bornstein, Stefan R.; Kristiansson, Kati; Perola, Markus; Lindström, Jaana; Atalay, Mustafa; Lakka, Timo A.; Bolton, Jennifer L.; Fowkes, Gerry; Mathieson, Iain; Fraser, Ross M.; Krjutå Kov, Kaarel; Fischer, Krista; Krjutå¡kov, Kaarel; Metspalu, Andres; Fr, Day; Mihailov, Evelin; KrjutÅkov, K.; Langenberg, Claudia; Ong, Ken Kk; Luan, Jian An; Chines, Peter S.; Keinanen-Kiukaanniemi, Sirkka M.; Edkins, Sarah; Kov, Kaarel Krjutå; Franks, Paul W.; Hallmans, Göran; Morris, Andrew David; Palmer, Colin N. A.; Erbel, Raimund; Moebus, Susanne; Nothen, Markus Mm; Pechlivanis, Sonali; Hveem, Kristian; Narisu, Narisu; Hamsten, Anders; Humphries, Steve E.; Grallert, Harald; Krjutaikov, Kaarel; Magic, Investigators; Illig, Thomas; Müller-Nurasyid, Martina; Koenig, Wolfgang; Müller-Nurasyid, Martina; Diagram, Consortium; Peters, Annette; Boehm, Bernhard O.; Kleber, Marcus E.; März, Winfried; Kuusisto, Johanna; Laakso, Markku; Arveiler, Dominique; Cesana, Giancarlo; Kuulasmaa, Kari; März, Winfried; Price, Jackie F.; Kuh, Diana; Lind, Lars; Gigante, Bruna; Magnusson, Patrik K. E.; Mueller-Nurasyid, Martina; Pedersen, Nancy L.; Dedoussis, George; Dimitriou, Maria; Kolovou, Genovefa; Maerz, Winfried; Kanoni, Stavroula; Bonnycastle, Lori Ll; Njølstad, Inger; Faire, Ulf; Ae, Locke; Ganna, Andrea; Hingorani, Aroon; Kivimaki, Mika; Kumari, Meena; Assimes, Themistocles L.; Barroso, Inês; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Frayling, Timothy; Groop, Leif C.; Haritunians, Talin; Hunter, David; Ingelsson, Erik; Kaplan, Robert; Klauw, Melanie M.; Mohlke, Karen L.; O'Connell, Jeffrey R.; Abecasis, Gonçalo R.; McCarthy, Mark I.; Hirschhorn, Joel N.; O’connell, Jeffrey R.; Loos, Ruth J. F.; Lindgren, Cecilia M.; North, Kari E.; Heid, Iris M.; Gibson, Greg

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Martin Den Heijer
van der Klauw et al., 2013

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@article{van der Klauw2013,
  abstract = {Public Library of Science open access ; Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR},
  author = {van der Klauw, M. M. and van Vliet-Ostaptchouk, J. and da Morris, A. and Zhao, Jing Hua and Zillikens, Mc Carola and den Heijer, Martin and van der Harst, Pim and Yang, Jian and Yarnell, John W. G. and de Faire, Ulf and van Duijn, Cornelia M. and Randall, Joshua C. and Winkler, Thomas W. and Vedantam, Sailaja and Wood, Andrew R. and Steinthorsdottir, Valgerdur and Thorleifsson, Gudmar and Prokopenko, Inga and Waite, Lindsay Ll and Smith, Albert Vernon and Shuldiner, Alan R. and Thorsteinsdottir, Unnur and Teder-Laving, Maris and Tw, Winkler and Wareham, Nicholas J. and Province, Michael A. and Ripatti, Samuli and Surakka, Ida and Saramies, Jouko and Tuomilehto, Jaakko and Salomaa, Veikko and Schunkert, Heribert and Wichmann, He Erich and Voelzke, Henry and Speliotes, Elizabeth K. and Toenjes, Anke and Wilson, James F. and Uitterlinden, André G G. and Rivadeneira, Fernando and Tyrer, Jonathan and Si, Berndt and Teumer, Alexander and Völzke, Henry and Tönjes, Anke and Tonu, Esko and Spector, Tim D. and Rudan, Igor and Samani, Nilesh J. and Sambrook, Jennifer G. and Vliet-Ostaptchouk, Jana and Sinisalo, Juha and Rivolta, Carlo and Jc, Randall and Tönjes, Anke and Snieder, Harold and Van der Klauw, Melanie Mm and Van Vliet-Ostaptchouk, Jana V. and Shi, Jianxin and Wang, Zhaoming and Ridker, Paul M. and Rose, Lynda M. and Raitakari, Olli and Sager, Hendrik and Schwarz, Peter E. H. and Swift, Amy J. and Kutalik, Zoltán and Uusitupa, Matti and Rauramaa, Rainer and Saaristo, Timo E. and Shungin, Dmitry and Strawbridge, Rona J. and Tremoli, Elena and Thorand, Barbara and To, Kilpeläinen and Winkelmann, Bernhard R. and Virtamo, Jarmo and Wong, Andrew and Stirrups, Kathleen and Wilsgaard, Tom and Rehnberg, Emil and Schlessinger, David and Strachan, David P. and Stefansson, Kari and Qi, Lu and Berndt, Sonja I. and Jackson, Anne U. and Monda, Keri L. and Kilpeläinen, Tuomas O. and Maegi, Reedik and Feitosa, Mary F. and Harst, Pim and Croteau-Chonka, Damien C. and Workalemahu, Tsegaselassie and Li, Shengxu and Day, Felix R. and Mägi, Reedik and Locke, Adam E. and Liang, Liming and Dermitzakis, Emmanouil T. and Dimas, Antigone S. and Karpe, Fredrik and Min, Josine L. and Nicholson, George and Clegg, Deborah J. and Person, Thomas and Au, Jackson and Krohn, Jon P. and Bauer, Sabrina and Buechler, Christa and Eisinger, Kristina and Bonnefond, Amélie and Froguel, Philippe and Hottenga, Jouke-Jan and Esko, Tõnu and Gronberg, Henrik and Harris, Tamara B. and McArdle, Wendy L. and Caulfield, Mark J. and Munroe, Patricia B. and Grönberg, Henrik and Chen, Yii-Der Ida and Li, Guo and Kl, Monda and Beckmann, Jacques S. and Johnson, Toby and Khaw, Kay-Tee and Mägi, Reedik and Amin, Najaf and Adrienne Cupples, L. and Oostra, Ben A. and Kraja, Aldi T. and Cupples, La Adrienne and Heard-Costa, Nancy L. and Kaprio, Jaakko and Collins, Francis S. and O. Connell, Jeffrey R. and Jula, Antti and Kilpelaeinen, Tuomas O. and Erdmann, Jeanette and Hengstenberg, Christian and Loley, Christina and Lamina, Claudia and Albrecht, Eva and Johansson, Å. and Gieger, Christian and Johansson, Åsa and Erich Wichmann, H. and Hicks, Andrew Aa and Pramstaller, Peter Pp and Kathiresan, Sekar and Li, S. and Penninx, Brenda and Hartikainen, Anna-Liisa and Jarvelin, Marjo-Riitta and Gyllensten, Ulf and Boomsma, Dorret I. and Campbell, Harry and Chanock, Stephen J. and Farrall, Martin and Goel, Anuj and Medina-Gomez, Carolina and Johansson, Åsa and Estrada, Karol and Hofman, Albert and Kiemeney, Lambertus A. and Duijn, Cornelia M. and Maschio, Andrea and Hall, Per and Scherag, Andre and Carola Zillikens, M. and Heijer, Martin den and Kovacs, Peter and Mangino, Massimo and Hayward, Caroline and Hall, Alistair S. and Attwood, Antony Paul and Hung, Joseph and Palmer, Lyle J. and Lokki, Marja-Liisa and Boucher, Gabrielle and Fall, Tove and Huikuri, Heikki and Lorentzon, Mattias and Ohlsson, Claes and Hyppoenen, Elina and Eklund, Niina and Eriksson, Johan G. and Barlassina, Cristina and Nolte, Ilja M. and Gejman, Pablo V. and Ferreira, Teresa and Jacobs, Kevin B. and Bakker, Stephan J. L. and Mateo Leach, Irene and Navis, Gerjan and Martin, Nicholas G. and Medland, Sarah E. and Montgomery, Grant W. and Chasman, Daniel I. and Mf, Feitosa and Leach, Irene Mateo and Lehtimäki, Terho and Gustafsson, Stefan and Absher, Devin and Iribarren, Carlos and Basart, Hanneke and Hovingh, Kees G. and Hyppönen, Elina and Power, Chris and Anderson, Denise and Beilby, John P. and Hui, Jennie and Jolley, Jennifer and Dc, Croteau Chonka and Noethen, Markus M. and Bornstein, Stefan R. and Kristiansson, Kati and Perola, Markus and Lindström, Jaana and Atalay, Mustafa and Lakka, Timo A. and Bolton, Jennifer L. and Fowkes, Gerry and Mathieson, Iain and Fraser, Ross M. and Krjutå Kov, Kaarel and Fischer, Krista and Krjutå¡kov, Kaarel and Metspalu, Andres and Fr, Day and Mihailov, Evelin and KrjutÅkov, K. and Langenberg, Claudia and Ong, Ken Kk and Luan, Jian An and Chines, Peter S. and Keinanen-Kiukaanniemi, Sirkka M. and Edkins, Sarah and Kov, Kaarel Krjutå and Franks, Paul W. and Hallmans, Göran and Morris, Andrew David and Palmer, Colin N. A. and Erbel, Raimund and Moebus, Susanne and Nothen, Markus Mm and Pechlivanis, Sonali and Hveem, Kristian and Narisu, Narisu and Hamsten, Anders and Humphries, Steve E. and Grallert, Harald and Krjutaikov, Kaarel and Magic, Investigators and Illig, Thomas and Müller-Nurasyid, Martina and Koenig, Wolfgang and Müller-Nurasyid, Martina and Diagram, Consortium and Peters, Annette and Boehm, Bernhard O. and Kleber, Marcus E. and März, Winfried and Kuusisto, Johanna and Laakso, Markku and Arveiler, Dominique and Cesana, Giancarlo and Kuulasmaa, Kari and März, Winfried and Price, Jackie F. and Kuh, Diana and Lind, Lars and Gigante, Bruna and Magnusson, Patrik K. E. and Mueller-Nurasyid, Martina and Pedersen, Nancy L. and Dedoussis, George and Dimitriou, Maria and Kolovou, Genovefa and Maerz, Winfried and Kanoni, Stavroula and Bonnycastle, Lori Ll and Njølstad, Inger and Faire, Ulf and Ae, Locke and Ganna, Andrea and Hingorani, Aroon and Kivimaki, Mika and Kumari, Meena and Assimes, Themistocles L. and Barroso, Inês and Boehnke, Michael and Borecki, Ingrid B. and Deloukas, Panos and Fox, Caroline S. and Frayling, Timothy and Groop, Leif C. and Haritunians, Talin and Hunter, David and Ingelsson, Erik and Kaplan, Robert and Klauw, Melanie M. and Mohlke, Karen L. and O'Connell, Jeffrey R. and Abecasis, Gonçalo R. and McCarthy, Mark I. and Hirschhorn, Joel N. and O’connell, Jeffrey R. and Loos, Ruth J. F. and Lindgren, Cecilia M. and North, Kari E. and Heid, Iris M. and Gibson, Greg},
  doi = {10.1371/journal.pgen.1003500},
  month = {jun},
  title = {Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits},
  url = {http://dx.doi.org/10.1371/journal.pgen.1003500},
  year = {2013}
}

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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Journal article published in 2013 by M. M. van der Klauw, J. van Vliet-Ostaptchouk, A. da Morris, Jing Hua Zhao, Mc Carola Zillikens, Martin den Heijer

, Pim van der Harst, Jian Yang, John W. G. Yarnell, Ulf de Faire, Cornelia M. van Duijn, Joshua C. Randall, Thomas W. Winkler, Sailaja Vedantam, Andrew R. Wood and other authors. M. M. van der Klauw, J. van Vliet-Ostaptchouk, A. da Morris, Jing Hua Zhao, Mc Carola Zillikens, Martin den Heijer

, Pim van der Harst, Jian Yang, John W. G. Yarnell, Ulf de Faire, Cornelia M. van Duijn, Joshua C. Randall, Thomas W. Winkler, Sailaja Vedantam, Andrew R. Wood, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Inga Prokopenko, Lindsay Ll Waite, Albert Vernon Smith

, Alan R. Shuldiner, Unnur Thorsteinsdottir, Maris Teder-Laving, Winkler Tw, Nicholas J. Wareham, Michael A. Province, Samuli Ripatti, Ida Surakka, Jouko Saramies, Jaakko Tuomilehto, Veikko Salomaa, Heribert Schunkert, He Erich Wichmann, Henry Voelzke, Elizabeth K. Speliotes, Anke Toenjes, James F. Wilson, André G G. Uitterlinden, Fernando Rivadeneira, Jonathan Tyrer, Berndt Si, Alexander Teumer, Henry Völzke, Anke Tönjes, Esko Tonu, Tim D. Spector, Igor Rudan, Nilesh J. Samani, Jennifer G. Sambrook, Jana Vliet-Ostaptchouk, Juha Sinisalo, Carlo Rivolta, Randall Jc, Anke Tönjes, Harold Snieder, Melanie Mm Van der Klauw, Jana V. Van Vliet-Ostaptchouk, Jianxin Shi, Zhaoming Wang, Paul M. Ridker, Lynda M. Rose, Olli Raitakari, Hendrik Sager, Peter E. H. Schwarz, Amy J. Swift, Zoltán Kutalik, Matti Uusitupa, Rainer Rauramaa, Timo E. Saaristo, Dmitry Shungin, Rona J. Strawbridge, Elena Tremoli, Barbara Thorand, Kilpeläinen To, Bernhard R. Winkelmann, Jarmo Virtamo, Andrew Wong, Kathleen Stirrups, Tom Wilsgaard, Emil Rehnberg, David Schlessinger, David P. Strachan, Kari Stefansson, Lu Qi, Sonja I. Berndt, Anne U. Jackson, Keri L. Monda, Tuomas O. Kilpeläinen, Reedik Maegi, Mary F. Feitosa, Pim Harst, Damien C. Croteau-Chonka, Tsegaselassie Workalemahu, Shengxu Li, Felix R. Day, Reedik Mägi, Adam E. Locke

, Liming Liang, Emmanouil T. Dermitzakis, Antigone S. Dimas, Fredrik Karpe, Josine L. Min, George Nicholson, Deborah J. Clegg, Thomas Person, Jackson Au, Jon P. Krohn, Sabrina Bauer, Christa Buechler, Kristina Eisinger, Amélie Bonnefond

, Philippe Froguel, Jouke-Jan Hottenga, Tõnu Esko

, Henrik Gronberg, Tamara B. Harris, Wendy L. McArdle, Mark J. Caulfield, Patricia B. Munroe, Henrik Grönberg, Yii-Der Ida Chen, Guo Li, Monda Kl, Jacques S. Beckmann, Toby Johnson, Kay-Tee Khaw, Reedik Mägi, Najaf Amin, L. Adrienne Cupples, Ben A. Oostra, Aldi T. Kraja, La Adrienne Cupples, Nancy L. Heard-Costa, Jaakko Kaprio, Francis S. Collins, Jeffrey R. O. Connell, Antti Jula, Tuomas O. Kilpelaeinen, Jeanette Erdmann, Christian Hengstenberg, Christina Loley, Claudia Lamina, Eva Albrecht, Å. Johansson, Christian Gieger

, Åsa Johansson, H. Erich Wichmann, Andrew Aa Hicks, Peter Pp Pramstaller

, Sekar Kathiresan, S. Li, Brenda Penninx, Anna-Liisa Hartikainen, Marjo-Riitta Jarvelin, Ulf Gyllensten, Dorret I. Boomsma, Harry Campbell, Stephen J. Chanock, Martin Farrall, Anuj Goel, Carolina Medina-Gomez, Åsa Johansson, Karol Estrada, Albert Hofman, Lambertus A. Kiemeney, Cornelia M. Duijn, Andrea Maschio, Per Hall, Andre Scherag, M. Carola Zillikens, Martin den Heijer, Peter Kovacs, Massimo Mangino, Caroline Hayward, Alistair S. Hall, Antony Paul Attwood, Joseph Hung, Lyle J. Palmer, Marja-Liisa Lokki, Gabrielle Boucher, Tove Fall, Heikki Huikuri, Mattias Lorentzon, Claes Ohlsson, Elina Hyppoenen, Niina Eklund, Johan G. Eriksson, Cristina Barlassina, Ilja M. Nolte, Pablo V. Gejman, Teresa Ferreira, Kevin B. Jacobs, Stephan J. L. Bakker, Irene Mateo Leach, Gerjan Navis, Nicholas G. Martin

, Sarah E. Medland, Grant W. Montgomery, Daniel I. Chasman, Feitosa Mf, Irene Mateo Leach, Terho Lehtimäki, Stefan Gustafsson, Devin Absher, Carlos Iribarren, Hanneke Basart, Kees G. Hovingh, Elina Hyppönen

, Chris Power, Denise Anderson, John P. Beilby, Jennie Hui, Jennifer Jolley, Croteau Chonka Dc, Markus M. Noethen, Stefan R. Bornstein, Kati Kristiansson, Markus Perola, Jaana Lindström, Mustafa Atalay, Timo A. Lakka, Jennifer L. Bolton, Gerry Fowkes, Iain Mathieson, Ross M. Fraser, Kaarel Krjutå Kov, Krista Fischer, Kaarel Krjutå¡kov, Andres Metspalu, Day Fr, Evelin Mihailov, K. KrjutÅkov, Claudia Langenberg, Ken Kk Ong, Jian An Luan, Peter S. Chines, Sirkka M. Keinanen-Kiukaanniemi, Sarah Edkins, Kaarel Krjutå Kov, Paul W. Franks, Göran Hallmans, Andrew David Morris, Colin N. A. Palmer, Raimund Erbel, Susanne Moebus, Markus Mm Nothen, Sonali Pechlivanis, Kristian Hveem, Narisu Narisu, Anders Hamsten, Steve E. Humphries, Harald Grallert, Kaarel Krjutaikov, Investigators Magic, Thomas Illig, Martina Müller-Nurasyid, Wolfgang Koenig, Martina Müller-Nurasyid, Consortium Diagram, Annette Peters, Bernhard O. Boehm, Marcus E. Kleber, Winfried März, Johanna Kuusisto, Markku Laakso, Dominique Arveiler, Giancarlo Cesana, Kari Kuulasmaa, Winfried März, Jackie F. Price

, Diana Kuh, Lars Lind, Bruna Gigante, Patrik K. E. Magnusson, Martina Mueller-Nurasyid, Nancy L. Pedersen, George Dedoussis, Maria Dimitriou, Genovefa Kolovou, Winfried Maerz, Stavroula Kanoni, Lori Ll Bonnycastle, Inger Njølstad, Ulf Faire, Locke Ae, Andrea Ganna, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Themistocles L. Assimes, Inês Barroso, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas

, Caroline S. Fox, Timothy Frayling, Leif C. Groop, Talin Haritunians, David Hunter, Erik Ingelsson, Robert Kaplan, Melanie M. Klauw, Karen L. Mohlke, Jeffrey R. O'Connell, Gonçalo R. Abecasis, Mark I. McCarthy, Joel N. Hirschhorn, Jeffrey R. O’connell, Ruth J. F. Loos, Cecilia M. Lindgren, Kari E. North, Iris M. Heid, Greg Gibson

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Abstract

Public Library of Science open access ; Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR

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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Abstract