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Nature Research, Nature Communications, (7), p. 10494

DOI: 10.1038/ncomms10494

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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Journal article published in 2016 by Tuomas O. (Tuomas) Kilpeläinen, Jayne F. Martin Carli, Alicja A. (Alicja A.) Skowronski, Qi Sun, Jennifer Kriebel, Åsa K. Hedman ORCID, Mary F. (Mary Furlan) Feitosa, Asa K. (Asa) Hedman, Alexander W. Drong, James E. (James E.) Hayes, Jinghua H. Zhao, Tune H. (Tune) Pers, Ursula M. (Ursula) Schick, Niels Grarup, Zoltán Kutalik and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P