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BioMed Central, Biology Direct, 1(4), 2009

DOI: 10.1186/1745-6150-4-24

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Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea

Journal article published in 2009 by Jan-Peter Daniels, Steven Kelly ORCID, Bill Wickstead ORCID, Keith Gull
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract The transcription machineries of Archaea and eukaryotes are similar in many aspects, but little is understood about archaeal chromatin and its role in transcription. Here, we describe the identification in hyperthermophilic Crenarchaeota and a Korarchaeon of an orthologue of the eukaryotic transcription elongation factor Elf1, which has been shown to function in chromatin structure maintenance of actively transcribed templates. Our discovery has implications for the relationship of chromatin and transcription in Archaea and the evolution of these processes in eukaryotes. Reviewers This article was reviewed by Chris P. Ponting and Eugene V. Koonin.