Ixeris sonchifolia Hance, a normal perennial herb, has effects on appendicitis, headache, menstruation, blood circulation, blood stasis, pain, fibrinolytic enzymes, thrombus formation, coronary artery, myocardial infarct size, PGI2, ET, TXA2, TNF-, alpha IL-6 and IL-8, etc. However, there was no full coverage about the molecular basis and gene targets of Ixeris sonchifolia injection. PubChem Database and DAVID Database had been used conjunctively to detect the gene IDs, gene targets and their functions. There were 3008 genes found in the final results, 16 kinds of definite functions had been detected, 9 of which had been proved and the effects were focused on the psychological, immune, neurological, metabolic, cardiovascular and cancer functions. Ixeris sonchifolia had a wide effects on various symptoms, which had been reported by previous experiments and verified by this research; however its influences on aging, chemdependency, developmental, normalvariation, reproduction, pharmacogenomic and psychologic functions should be confirmed in the future experiments.