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Elsevier, Theoretical Population Biology, 4(72), p. 539-546, 2007

DOI: 10.1016/j.tpb.2007.08.001

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The SMM model as a boundary value problem using the discrete diffusion equation

Journal article published in 2007 by Joel Campbell ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A generalized single-step stepwise mutation model (SMM) is developed that takes into account an arbitrary initial state to a certain partial difference equation. This is solved in both the approximate continuum limit and the more exact discrete form. A time evolution model is developed for Y DNA or mtDNA that takes into account the reflective boundary modeling minimum microsatellite length and the original difference equation. A comparison is made between the more widely known continuum Gaussian model and a discrete model, which is based on modified Bessel functions of the first kind. A correction is made to the SMM model for the probability that two individuals are related that takes into account a reflecting boundary modeling minimum microsatellite length. This method is generalized to take into account the general n-step model and exact solutions are found. A new model is proposed for the step distribution.