Published in

Elsevier, Trends in Genetics, 8(21), p. 436-440

DOI: 10.1016/j.tig.2005.06.003



Export citation

Search in Google Scholar

Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences

Journal article published in 2005 by Klaudia Walter ORCID, Irina Abnizova, Greg Elgar, Walter R. Gilks
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Orange circle
Postprint: archiving restricted
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO


In a recent study, 1373 highly conserved non-coding elements (CNEs) were detected by aligning the human and Takifugu rubripes (Fugu) genomes. The remarkable degree of sequence conservation in CNEs compared with their surroundings suggested comparing the base composition within CNEs with their 5' and 3' flanking regions. The analysis reveals a novel, sharp and distinct signal of nucleotide frequency bias precisely at the border between CNEs and flanking regions.