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Elsevier, The Lancet Neurology, 9(8), p. 810-818

DOI: 10.1016/s1474-4422(09)70204-2

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Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up

Journal article published in 2009 by Linda Douw, Martin Klein ORCID, Selene Saa Fagel, Josje van den Heuvel, Martin Jb Taphoorn, Neil K. Aaronson, Tjeerd J. Postma, W. Peter Vandertop, Jacob J. Mooij, Rudolf H. Boerman, Guus N. Beute, Jasper D. Sluimer, Ben J. Slotman, Jaap C. Reijneveld, Jan J. Heimans
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Abstract

Our previous study on cognitive functioning among 195 patients with low-grade glioma (LGG) a mean of 6 years after diagnosis suggested that the tumour itself, rather than the radiotherapy used to treat it, has the most deleterious effect on cognitive functioning; only high fraction dose radiotherapy (>2 Gy) resulted in significant added cognitive deterioration. The present study assesses the radiological and cognitive abnormalities in survivors of LGG at a mean of 12 years after first diagnosis.