Royal Society of Chemistry, Green Chemistry, 7(16), p. 3454-3457, 2014
DOI: 10.1039/c4gc00386a
Wiley-VCH Verlag, ChemInform, 51(45), p. no-no, 2014
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Domino nucleophilic addition was used for four-component Al2O3-catalyzed environmentally friendly synthesis of polysubstituted β-cyanopropan-1-one. Domino nucleophilic addition involves removal of the cyano group linked to active methylene by the action of KF, and direct addition to enones. The reaction's capability for nucleophilic attack is F− > CN− in DMF. The use of low-toxicity reagents hints that the reaction is more environmentally friendly than traditional approaches.