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Sociedade Brasileira de Cirurgia Cardiovascular, Revista Brasileira de Cirurgia Cardiovascular

DOI: 10.5935/1678-9741.20150045

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Effects of intraoperative diltiazem infusion on flow changes in arterial and venous grafts in coronary artery bypass graft surgery

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Objective: This study aimed to show the effects of intra-operative diltiazem infusion on flow in arteriel and venous grafts in coronary artery bypass graft surgery. Patients and Methods: 140 patients with a total of 361 grafts [205 (57%) arterial and 156 (43%) venous] underwent isolated coronary surgery. All the grafts were measured by intraoperative transit time flow meter intra-operatively. Group A (n=70) consisting of patients who received diltiazem infusion (dose of 2.5 microgram/kg/min), and Group B (n=70) who didn't receive diltiazem infusion. Results: Mean graft flow values of left internal mammary artery were 53 ml/min in Group A and 40 ml/min in Group B (P < 0.001). Pulsatility index (PI) values of left internal mammary artery for Group A and Group B were 2.6 and 3.0 respectively (P < 0.001). No statistically significant difference was found between venous graft parameters. Conclusion: We suggest an effect of diltiazem infusion in preventing early vasospasm and in increasing graft flows in coronary artery bypass graft operations.