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Sociedade Brasileira de Química, SBQ, Journal of the Brazilian Chemical Society, 6b(16), p. 1360-1366, 2005

DOI: 10.1590/s0103-50532005000800009

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A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity

Journal article published in 2005 by Paula Boeck, Boeck,Paula, Marcus M. Sá, Bruno S. de Souza ORCID, Sá,Marcus M., Souza,Bruno S. De, Rodrigo Cercená, Susana A. Zachino, Cercená,Rodrigo, Andréa M. Escalante, Rosendo A. Yunes, Escalante,Andréa M., Zachino,Susana A., Valdir Cechinel Filho, Cechinel Filho,Valdir and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Representative esters derived from kaurenoic acid were prepared in order to evaluate their antifungal properties. Alkyl and substituted benzyl esters were obtained in good yield under mild conditions by esterification of kaurenoic acid with the corresponding alkyl halide in KOH-acetone. All synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophytes. Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes.