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MDPI, Molecules, 12(19), p. 20880-20887, 2014

DOI: 10.3390/molecules191220880

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Two New Coumarins from Talaromyces flavus

Journal article published in 2014 by Jun-Wei He, Da-Peng Qin, Hao Gao, Run-Qiao Kuang, Yang Yu, Xing-Zhong Liu, Xin-Sheng Yao
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher's method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aβ42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ42 aggregation activity, and this is the first report on the Aβ42 inhibitory aggregation activity of coumarins.