Biofuel Backfire For compelling economical, geopolitical, and environmental reasons, biofuels are considered an attractive alternative to fossil fuels for meeting future global energy demands. Melillo et al. (p. 1397 , published online 22 October), however, suggest that a few serious drawbacks related to land use need to be considered. Based on a combined biogeochemistry and economic model, indirect land use (for example, clearing forested land for food crops to compensate for increased biofuel crop production on current farmlands) is predicted to generate more soil carbon loss than directly harvesting biofuel crops. Furthermore, increased fertilizer use for biofuels will add large amounts of nitrous oxide—a more effective heat-trapping molecule than carbon dioxide—to the atmosphere. Policy decisions regarding land and crop management thus need to consider the long-term implications of increased biofuel production.