Published in
American Association for the Advancement of Science, Science Translational Medicine, 291(7), 2015
DOI: 10.1126/scitranslmed.aaa9223
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Genetic variants associated with autoimmunity drive NF$κ$B signaling and responses to inflammatory stimuli
Journal article published in 2015 by
William J. Housley,
Salvador D. Fernandez,
Kenneth Vera,
Sasidhar R. Murikinati,
Jaime Grutzendler,
Nicole Cuerdon,
Laura Glick,
Phillip L. De Jager,
Mitja Mitrovic,
Chris Cotsapas 
,
David A. Hafler,
Others
,
David A. Hafler,
Others
This paper is available in a repository.
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Abstract
Genetic variants associated with multiple sclerosis result in increased NFκB signaling in CD4 T cells and a decreased threshold for activation.