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American Physical Society, Physical Review Letters, 2(112), 2014

DOI: 10.1103/physrevlett.112.028101

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Reentrant Liquid-Liquid Phase Separation in Protein Solutions at Elevated Hydrostatic Pressures

This paper is available in a repository.
This paper is available in a repository.

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Abstract

We present results from small-angle x-ray scattering data on the effect of high pressure on the phase behavior of dense lysozyme solutions in the liquid-liquid phase separation region, and characterize the underlying intermolecular protein-protein interactions as a function of temperature and pressure in this region of phase space. A reentrant liquid-liquid phase separation region has been discovered at elevated pressures, which originates in the pressure dependence of the solvent-mediated protein-protein interactions.