Published in
Elsevier, European Journal of Medicinal Chemistry, (106), p. 15-25, 2015
DOI: 10.1016/j.ejmech.2015.10.030
Links
Tools
Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines
,
Said Yous ,
Noémie Deguine,
Luc Buée ,
Philippe Chavatte,
David Blum,
Luisa Lopes,
Patricia Melnyk,
Laurence Agouridas
Full text: Download
Abstract
In the aim of identifying new privileged structures, we describe the 5-steps synthesis of cyclic guanidine compounds "tetrahydroisoquinoline-iminoimidazolines" derived from tetrahydroisoquinoline-hydantoin core. In order to evaluate this new minimal structure and the impact of replacing a carbonyle by a guanidine moiety, their affinity towards adenosine receptor A2A was evaluated and compared to those of tetrahydroisoquinoline-hydantoin compounds.