Published in

Nature Research, Nature Methods, 1(12), p. 47-50, 2014

DOI: 10.1038/nmeth.3183

Elsevier, Biophysical Journal, 2(108), p. 355a, 2015

DOI: 10.1016/j.bpj.2014.11.1943

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Acoustic Force Spectroscopy

Journal article published in 2014 by Douwe Kamsma, Gerrit Sitters, Gregor Thalhammer ORCID, Monika Ritsch-Marte, Erwin J. G. Peterman ORCID, Gijs J. L. Wuite ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.