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Springer Nature [academic journals on nature.com], Molecular Psychiatry, 6(19), p. 668-675, 2013

DOI: 10.1038/mp.2013.68

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708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

Journal article published in 2013 by P. A. Thomson, J. S. Parla, A. F. McRae, M. Kramer, K. Ramakrushnan, K. Ramakrishnan, J. Yao, D. C. Soares, S. McCarthy, S. W. Morris, L. Cardone, S. Cass, E. Ghiban, W. Hennah ORCID, K. L. Evans and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single large Scottish family, but genome-wide and exome sequencing-based association studies have not supported a role for DISC1 in psychiatric illness. To explore DISC1 in more detail, we sequenced 528 kb of the DISC1 locus in 653 cases and 889 controls. We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of