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Nature Research, Nature Genetics, 12(45), p. 1452-1458, 2013

DOI: 10.1038/ng.2802

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease

Journal article published in 2013 by H. van den Bussche, Genetic And Environmental Risk in Alzheimer's Disease (GERAD), Cohorts For Heart And Aging Research in Genomic Epidemiology (CHARGE), Maria Del Zompo, C. Van Cauwenberghe, R. Vandenberghe, H. Thonberg, Mosley Th, Harris Tb, Beach Tg, Bird Td, Montine Tj, Foroud Tm, Kukull Wa, Mack Wj and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.