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Public Library of Science, PLoS ONE, 10(10), p. e0140496, 2015

DOI: 10.1371/journal.pone.0140496

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Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

Journal article published in 2015 by Joshua C. Bis, Colleen Sitlani, Ryan Irvin, Christy L. Avery, Albert Vernon Smith ORCID, Fangui Sun, Daniel S. Evans, Solomon K. Musani, Xiaohui Li, Stella Trompet, Bouwe P. Krijthe, Tamara B. Harris, P. Miguel Quibrera, P. Miguel Quibrera, Jennifer A. Brody and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individuals are prescribed antihypertensive medications. Although large long-term clinical trials conducted in the last several decades have identified a number of effective antihypertensive treatments that reduce the risk of future clinical complications, responses to therapy and protection from cardiovascular events vary among individuals.