Dissemin is shutting down on January 1st, 2025

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2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

DOI: 10.1109/embc.2014.6945060

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On-off closed-loop control of vagus nerve stimulation for the adaptation of heart rate

Proceedings article published in 2014 by Hector Romero Ugalde, Virginie Le Rolle ORCID, Virginie Le Rolle, Alain Bel, Jean-Luc Bonnet, Hector M. Romero Ugalde, David Andreu, Philippe Mabo, Guy Carrault, Alfredo I. Hernández
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This paper is available in a repository.

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Abstract

Vagus nerve stimulation (VNS) is a potential therapeutic approach in a number of clinical applications. Although VNS is commonly delivered in an open-loop approach, it is now recognized that closed-loop approaches may be necessary to optimize the therapy and minimize side effects of neuro-stimulation devices. In this paper, we describe a prototype system for real-time control of the instantaneous heart rate, working synchronously with the heart period. As a first step, an on-off control method has been integrated. The system is evaluated on one sheep with induced heart failure, showing the interest of the proposed approach.