Published in

Oxford University Press (OUP), Journal of Antimicrobial Chemotherapy, 2(61), p. 235-237

DOI: 10.1093/jac/dkm476

Links

Tools

Export citation

Search in Google Scholar

Tissue concentrations: Do we ever learn?

Journal article published in 2007 by Johan W. Mouton ORCID, Ursula Theuretzbacher, William A. Craig, Paul M. Tulkens, Hartmut Derendorf, Otto Cars
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Over the last decades, numerous papers have appeared--and still are appearing--that describe concentrations in tissues in an effort to predict the efficacy of an antimicrobial agent based on these concentrations and MICs for microorganisms. A common method is to use measurements of concentrations in tissue homogenates, comparing these with values derived from the corresponding blood samples and on that basis draw conclusions with respect to the potential clinical use of the drug. This approach is not justifiable for a number of reasons that includes both pharmacokinetic as well as pharmacodynamic causes. This way of presenting data with the derived conclusions is often misleading and may ultimately be harmful in patient care.