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BioMed Central, Respiratory Research, 1(16), 2015

DOI: 10.1186/s12931-015-0297-0

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Small airway epithelial-C/EBPβ is increased in patients with advanced COPD

Journal article published in 2015 by Michiko Mori, Leif Bjermer, Jonas S. Erjefält, Martin R. Stampfli ORCID, Abraham B. Roos
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.