Cell Press, Molecular Cell, 1(55), p. 1-3, 2014
DOI: 10.1016/j.molcel.2014.06.022
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In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4.